Mathematical modelling of ionic electrodiffusion and water movement is emerging as a powerful avenue of investigation to provide new physiological insight into brain homeostasis. However, in order to provide solid answers and resolve controversies, the accuracy and precision of the predictions are essential. Here, we consider an homogenized model for ionic electrodiffusion and osmosis...
Osteosarcoma is a primary bone tumour that occurs mainly in adolescents and young adults. The survival rate at 5 years is 70% and drops to 25% for patients with metastases or poor responders to treatment [1]. Therapeutic strategies have not evolved for more than three decades and new developments are needed to improve the specific management of patients.
Like the majority of complex genomic...
Deep tissue injury often results in contraction of skin due to mechanical pulling forces exerted by skin cells (fibroblasts) in the dermal layer. If contractions are morbid, then they are referred to as contractures. Contractures cause disabilities to patients, by, for instance, loss of mobility of a joint. By the use of modeling, we aim at understanding the mechanisms behind the formation of...
Quantification of the full brain structural vasculature and physiological response is advantageous for improved understanding of cerebrovascular disease progression affecting the brain. In this respect, characterization of the whole brain angioarchitecture across multiple resolution scales from arteries and veins down to capillaries enables simulation of whole brain blood flow. In the current...
Capillaries are the most frequent vessel type of the brain’s vasculature. The dense and highly interconnected capillary bed is key to ensure a robust blood supply over the entire depth of the cortex, and during baseline and neuronal activation. Besides its relevance our knowledge of structural and functional properties of the capillary bed remains limited. We perform blood flow simulations in...
Due to the limited energy storage capabilities of the brain, maintaining a robust oxygen and nutrient supply to all regions of the brain is crucial. During healthy conditions, the interconnected network of blood vessels sustains blood flow to all brain areas. However, during stroke the overall blood supply is reduced drastically. This typically causes tissue damage, which often results in...
Percutaneous vertebroplasty is a medical procedure done for treating weakened or damaged vertebrae. In this procedure, a cement-like polymer (bone cement) is injected percutaneously into the inside of the vertebra, which is a porous trabecular structure. Upon curing, the bone cement restores the structural strength of the vertebra. While the procedure is fairly successful, there is a risk of...
