InterPore2021

Simulation of blood flow in a whole mouse brain vasculature

31 May 2021, 15:55

15m

Oral Presentation (MS20) Biophysics of living porous media: theory, experiment, modeling and characterization MS20

Speaker

Erlend Hodneland (NORCE Norwegian Research Centre)

Description

Quantification of the full brain structural vasculature and physiological response is advantageous for improved understanding of cerebrovascular disease progression affecting the brain. In this respect, characterization of the whole brain angioarchitecture across multiple resolution scales from arteries and veins down to capillaries enables simulation of whole brain blood flow. In the current work we are pioneering a blood flow simulator for a complete in silico mouse brain model previously segmented for vasculature. We report structural and functional parameters of the mouse brain angioarchitecture that to date have not been reported elsewhere.

References

Erlend Hodneland, Erik A. Hanson, Ove Sævareid, Geir Nævdal, Arvid Lundervold, Veronika Solteszova, Antonella Z. Munthe-Kaas, Andreas Deistung, Jurgen R. Reichenbach, Jan M. Nordbotten. “A new framework for assessing subject-specific whole brain circulation and perfusion using MRI-based measurements and a multi-scale continuous flow model”. PLOS Computational Biology (2019); 15(6):e1007073.