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Blood clots are a complex heterogeneous porous matrix primarily composed of platelets, red blood cells, and fibrin. This matrix composed of micron and sub-micron scale components results in pores on the order of microns, which causes high flow resistance through the clot in occluded vessels [1]. Elevated flow resistance in these occluded vessels, as occurs in cases of stroke or heart attack,...
Nanoparticles (NPs) have emerged as promising candidates for targeted drug delivery in the treatment of brain tumours due to their diverse physicochemical properties. With the advanced development of convection-enhanced delivery (CED), anticancer drugs are directly infused into the targeted brain tumour region through a catheter, enabling drugs to bypass the blood-brain barrier (BBB). Multiple...
The cerebral vasculature plays a vital role in nutrients delivery and metabolic waste removal in the brain, yet in which transport mechanisms are not fully understood. Numerical simulation is an effective approach for analyzing transport in the cerebral vasculature, depending on accurate acquisition of the cerebrovascular structure. However, the complex cerebrovascular structure poses a...
Cardiac microvascular obstruction (MVO) is an injury of the myocardial microcirculation. It typically follows successful recanalization of the blocked coronary artery (primary occlusion) in myocardial infarction. MVO leads to under-perfusion of the affected tissue and has a negative impact on patient outcomes. Next to other occluding factors, MVO may be caused by microthrombi (debris from the...
In cardiac microvascular obstruction (MVO), vessels of the myocardial microcirculation are fully or partially occluded such that the affected tissue is under-perfused. MVO may result from a catheter-based removal of a larger thrombus in a coronary artery after a heart attack. During the intervention, this thrombus may be broken up into small microthrombi, which are washed downstream with the...
Root water uptake efficiency and robustness to varying soil water distribution depend on the three-dimensional root system architecture.
Roots can also redistribute soil water through the root system. However, roots are numerous and thin which is why modeling root water uptake with three-dimensionally resolved roots is a numerical challenge. Moreover, soil hydraulic conductivity nonlinearly...
